Spectrophotometric Determination of Nitrazepam by Coupling of Diazotized Reduced Nitrazepam with N-(1-naphthyl)ethyl-enediamine Dihydrochloride

Facile Spectrophotometric Determination of Nimodipine and Nitrazepam in Pharmaceutical Preparations

abstract: A simple, accurate and sensitive visible spectrophotometric method for the determination of nimodipine (NMD) and nitrazepam (NTZ) is described. The method is based on the diazotization of reduced drugs with nitrous acid followed by coupling with resorcinol to form colored azo-dye in an alkaline medium. The resulting colored azo-dye exhibits maximum absorption peak at 480 nm for both N...

Spectrophotometric Assay of Nimodipine and Nitrazepam

Flow-injection spectrophotometric determination of phenolic drugs and carbamate pesticides by coupling with diazotized 2,4,6-trimethylaniline.

A flow-injection (FI) spectrophotometric system is proposed for the determination of phenols and carbamates. In the FI manifolds, the solutions of phenols or carbamates (the latter after hydrolysis with NaOH) were injected into a diazonium ion carrier stream at pH 9.5 (buffered with tetrahydroborate), which was formed by mixing 2,4,6-trimethylaniline (TMA) with nitrate in a sodium dodecyl sulfa...

Flow injection spectrophotometric determination of amoxicillin in pharmaceutical samples by coupling with diazotized p- nitroaniline

A spectrophotometric method using flow injection analysis (FIA) is described for the determination of amoxicillin (AMX). Its detection limit, linearity and reproducibility were examined.The automated method is based on a coupling reaction between AMX and diazotized paranitroaniline (DPNA) in alkaline medium to form an intense reddishorange, water-soluble dye that is stable and has a maximum abs...

Nitrazepam in premedication.

The sedative effects of nitrazepam in a dose of 5 mg and 10 mg have been compared with Mandrax, a combination of methaqualone 250 mg with diphenhydramine 25 mg. Studies were carried out in gynaecological patients undergoing minor surgical operations using the scoring system previously described. The degree of sedation obtained after administration of the two dose levels of nitrazepam was compar...